Larsson B, Skärby T, Edvinsson L, Hardebo J E, Owman C
Neurosci Lett. 1980 Apr;17(1-2):155-9. doi: 10.1016/0304-3940(80)90077-4.
A reversible opening of the structural blood-brain barrier (BBB) was accomplished in rats by rapidly increasing the hydrostatic pressure either through forced intracarotid infusion of autologous blood or i.v. administration of angiotensin, whose effect was exaggerated by previous injection of the vasodilator, papaverine. The extent of barrier damage was evaluated in terms of the extravasation of Evans blue-albumin complex or the brain uptake of circulating [14C]inulin. Pretreatment of the animals with the antimitotic agent, vincristine, significantly reduced the barrier damage. This is interpreted as an effect of vincristine on intracellular microtubule systems, which may be involved in the vesicular transport across the endothelial cells of brain microvessels.
通过强制颈内动脉输注自体血或静脉注射血管紧张素快速增加静水压力，可使大鼠的结构性血脑屏障（BBB）实现可逆性开放，血管舒张剂罂粟碱的预先注射会增强血管紧张素的这种作用。根据伊文思蓝 - 白蛋白复合物的外渗或循环中[14C]菊粉的脑摄取来评估屏障损伤程度。用抗有丝分裂剂长春新碱对动物进行预处理可显著降低屏障损伤。这被解释为长春新碱对细胞内微管系统的作用，细胞内微管系统可能参与脑微血管内皮细胞的囊泡运输。
