Jaffard R, Destrade C, Soumireu-Mourat B, Durkin T, Ebel A
Neurosci Lett. 1980 Oct 2;19(3):349-52. doi: 10.1016/0304-3940(80)90286-4.
A short bar-press operant conditioning acquisition session with food reward on continuous reinforcement was shown to induce a decrease (13.5%) of hippocampal choline acetyltransferase activity in mice. Such an effect seems to be specific to this kind of learning since no change was observed in several control groups, including a group of mice submitted to another type of conditioning in the same apparatus. It is suggested that these enzymatic modifications might be responsible for the delayed improvement of performance observed on retention of this task.
一项针对小鼠的短期压杆操作性条件反射习得实验，采用持续强化并给予食物奖励，结果显示该实验会使小鼠海马体中的胆碱乙酰转移酶活性降低（13.5%）。这种效应似乎是这种学习方式所特有的，因为在几个对照组中未观察到变化，包括一组在同一实验装置中接受另一种条件反射训练的小鼠。有观点认为，这些酶的修饰可能是导致在该任务记忆保持中观察到的行为表现延迟改善的原因。
