Bernstein J E, Swift R M, Soltani K, Lorincz A L
J Invest Dermatol. 1982 Jan;78(1):82-3. doi: 10.1111/1523-1747.ep12497974.
Central elicitation of itch by morphine may result from binding to opiate receptors, mimicking the physiological binding of endorphins and enkephalins to these receptors. Pretreatment of normal subjects with naloxone hydrochloride resulted in diminution or abolition of histamine-provoked itch. These results suggest an important role for central opioid peptides as mediators of the itch sensation.
吗啡对瘙痒的中枢性激发可能是由于其与阿片受体结合，模拟了内啡肽和脑啡肽与这些受体的生理性结合。用盐酸纳洛酮对正常受试者进行预处理，可减少或消除组胺诱发的瘙痒。这些结果表明中枢阿片肽作为瘙痒感觉的介质具有重要作用。
