da Rocha-Reis M G, Hipólito-Reis C
Br J Anaesth. 1982 Jan;54(1):97-101. doi: 10.1093/bja/54.1.97.
We have investigated the possible hepatic microsomal enzyme induction effect of enflurane, administered by inhalation in anaesthetic doses for periods of 1 h a day. In 15 experimental groups, differing from one another in anaesthetics concentration (1, 2 and 3% enflurane) and in the number of days of treatment (3, 7, 10, 14, 21 and 24) we found (1) no alteration either in the ratio of liver to body weight or in the microsomal protein content; (2) no modifications in aniline hydroxylase activity; (3) a decrease in the aminopyrine demethylase activity after a number of exposures, varying with the dose.
我们研究了安氟醚的肝微粒体酶诱导作用，每天以麻醉剂量吸入给药1小时。在15个实验组中，麻醉剂浓度（1%、2%和3%安氟醚）和治疗天数（3、7、10、14、21和24天）各不相同，我们发现：（1）肝重与体重之比或微粒体蛋白含量均无变化；（2）苯胺羟化酶活性无改变；（3）多次接触后，氨基比林脱甲基酶活性降低，降低程度随剂量而异。
