Feinstein D I
Thromb Haemost. 1978 Jun 30;39(3):663-74.
The clinical and laboratory data on the 12 patients with an acquired inhibitor to factor V have been reviewed. The degree of clinical bleeding in these patients varied from none to severe, and in most patients the inhibitor was transient. The combination of a markedly prolonged partial thromboplastin time and Quick prothrombin time and failure of normal plasma to correct these tests, in the presence of a normal thrombin and prothrombin and proconvertin time, seems to be pathognomonic for a factor V inhibitor. The inhibitors have physicochemical properties of immunoglobulins and a few have been characterized as polyclonal IgG antibodies or a mixture of IgM and IgG antibodies. The etiology and pathophysiologic mechanism of their development is unknown, but there seems to be a close relationship to major surgery. When tested with inhibitor plasma, the plasmas from 9 patients with hereditary factor V deficiency from 7 unrelated families did not contain factor V antibody-neutralizing material.
我们回顾了12例获得性凝血因子V抑制物患者的临床和实验室数据。这些患者的临床出血程度从无到严重不等，且大多数患者的抑制物是短暂性的。在凝血酶、凝血酶原和前转变素时间正常的情况下，部分凝血活酶时间和Quick凝血酶原时间显著延长，且正常血浆不能纠正这些检测结果，这似乎是凝血因子V抑制物的特征性表现。这些抑制物具有免疫球蛋白的理化特性，其中一些已被鉴定为多克隆IgG抗体或IgM与IgG抗体的混合物。其发生的病因和病理生理机制尚不清楚，但似乎与大手术密切相关。用抑制物血浆检测时，来自7个不相关家族的9例遗传性凝血因子V缺乏患者的血浆中不含有凝血因子V抗体中和物质。
