Tanaka T, Seki A, Fujii J
Tohoku J Exp Med. 1978 Sep;126(1):71-6. doi: 10.1620/tjem.126.71.
The weight and protein contents of the aorta and left ventricle were measured in rabbits with two-kidney or one-kidney Goldblatt hypertension (group 2H and group 1H) and in respective control animals (group 2C and group 1C). 14 days after a renal artery constriction the protein contents of the aorta were greater in group 2H (124+/-3 mg) than in group 2C (95+/-2 mg) (p less than 0.001) and in group 1H (124+/-5 mg) than in group 1C (102+/-4 mg) (p less than 0.001). The weight and protein contents of the aorta and of the left ventricle were also significantly greater in group 1H and group 2H than in group 1C and group 2C respectively. Furthermore in both types of hypertension the weight and protein contents of these two organs significantly correlated to the blood pressure. These results indicate that hypertrophy of the aorta as well as the left ventricle develops already in early developing stage of Goldblatt hypertension.
对两肾或一肾型Goldblatt高血压兔（2H组和1H组）及其相应的对照动物（2C组和1C组）测量主动脉和左心室的重量及蛋白质含量。肾动脉缩窄14天后，2H组主动脉的蛋白质含量（124±3mg）高于2C组（95±2mg）（p<0.001），1H组（124±5mg）高于1C组（102±4mg）（p<0.001）。1H组和2H组主动脉及左心室的重量和蛋白质含量也分别显著高于1C组和2C组。此外，在两种类型的高血压中，这两个器官的重量和蛋白质含量均与血压显著相关。这些结果表明，在Goldblatt高血压的早期发展阶段，主动脉和左心室就已出现肥大。
