长期服用锂可降低自发性高血压大鼠的血压。
Chronic lithium decreases blood pressure in spontaneously hypertensive rats.
作者信息
Baetge G, Koda L Y, Shoemaker W J
出版信息
Res Commun Chem Pathol Pharmacol. 1982 Jan;35(1):169-72.
The effects of chronic lithium treatment on the blood pressure of spontaneously hypertensive rats were examined. Treated rats were fed a pelleted solid diet containing 1.696 g LiCl (40 mmol) /Kg diet. Control rats received a similar diet lacking the lithium. Rats were fed their respective diet for 21 days at which time intra-arterial blood pressure was recorded while the rats were conscious and freely moving. Lithium treated rats had a decreased systolic (20-30 mmHg) and mean (15-20 mmHg) arterial blood pressure as compared to the control spontaneously hypertensive rats. Heart rate was increased in the lithium treated group.
研究了慢性锂治疗对自发性高血压大鼠血压的影响。将接受治疗的大鼠喂食含1.696 g LiCl（40 mmol）/kg饮食的颗粒状固体饮食。对照大鼠接受不含锂的类似饮食。大鼠分别喂食各自的饮食21天，此时在大鼠清醒且自由活动时记录动脉内血压。与对照自发性高血压大鼠相比，接受锂治疗的大鼠收缩压（降低20 - 30 mmHg）和平均动脉压（降低15 - 20 mmHg）有所下降。锂治疗组的心率增加。
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