Koda L Y, Shoemaker W J, Baetge G, Bloom F E
Eur J Pharmacol. 1981 Dec 17;76(4):411-5. doi: 10.1016/0014-2999(81)90112-6.
Chronic lithium treatment was examined for effects on the blood pressure of spontaneously hypertensive rats (SHRs). Treated rats were allowed continuous access to a pelleted lithium diet (1.7 g LiCl (40 mmol)/kg diet) for 21 days. Control SHRs were fed a similar diet lacking the lithium. Two groups of control rats were examined. One group had continuous access to control diet (ad lib controls); a second group was pair-fed a daily ration of control diet such that their mean body weight remained similar to the lithium treated group (pair-fed controls). Heart rate, systolic, diastolic and mean arterial blood pressures were recorded on day 21 from freely moving conscious rats. Systolic, diastolic and mean arterial blood pressure was significantly lower (approximately 15 mmHg) in the lithium treated SHRs as compared to either control group; the pair-fed and ad lib controls had similar blood pressures at the end of the treatment periods. Heart rate was increased in the lithium treated animals. All rats gained weight during the 21 days of treatment, although the lithium treated group and the pair-fed control group did not gain weight as much or as rapidly as the control group that had continuous access to control diet. Plasma and brain lithium levels were in the moderate range (0.3--0.4 meq/l) and all rats appeared healthy at the end of the experiment. These results suggest that chronic treatment may have clinically relevant effects on blood pressure.
研究了慢性锂治疗对自发性高血压大鼠（SHRs）血压的影响。给予治疗组大鼠连续21天自由摄取含锂颗粒饲料（1.7 g LiCl（40 mmol）/kg饲料）。对照SHRs喂养不含锂的类似饲料。检查了两组对照大鼠。一组可连续自由摄取对照饲料（自由摄食对照组）；另一组按日定量给予对照饲料进行配对喂养，使其平均体重与锂治疗组相似（配对喂养对照组）。在第21天，对自由活动的清醒大鼠记录心率、收缩压、舒张压和平均动脉血压。与任一对照组相比，锂治疗的SHRs的收缩压、舒张压和平均动脉血压显著降低（约15 mmHg）；在治疗期末，配对喂养组和自由摄食对照组的血压相似。锂治疗的动物心率增加。在21天的治疗期间，所有大鼠体重均增加，尽管锂治疗组和配对喂养对照组的体重增加量不如可连续自由摄取对照饲料的对照组多，增加速度也不如其快。血浆和脑锂水平处于中等范围（0.3--0.4 meq/l），在实验结束时所有大鼠看起来都很健康。这些结果表明，慢性治疗可能对血压有临床相关影响。
