聚磷酸根皮素及相关化合物对豚鼠胃平滑肌中前列腺素反应的抑制作用。

Inhibitory actions of polyphloretin phosphate and related compounds on the response to prostaglandin in the smooth muscle of guinea-pig stomach.

作者信息

Ishizawa M, Miyazaki E

出版信息

Prostaglandins. 1976 May;11(5):829-40. doi: 10.1016/0090-6980(76)90190-8.

Abstract

The inhibitory actions of polyphloretin phosphate (PPP) and related compounds, di-4-phloretin phosphate (DPP), PHLORETIN AND TRIHYDROXY PROPIOPHENONE (THPP) on the contractile responses to prostaglandin (PG) and acetylcholine (ACh) in longitudinal smooth muscle of guinea-pig stomach were studied. Of the four inhibitors PPP and DPP showed relatively selective antagonism for PGE1. DPP gave the highest pW2 value against PGE1. These results indicate that DPP is a useful antagonist of PG in smooth muscle, although it slightly inhibits responses to ACh, 5-HT or histamine, and the Ca-induced contracture in K depolarized preparation.

摘要

研究了聚磷酸根皮苷（PPP）及相关化合物二 - 4 - 磷酸根皮苷（DPP）、根皮苷和三羟基苯丙酮（THPP）对豚鼠胃纵行平滑肌对前列腺素（PG）和乙酰胆碱（ACh）收缩反应的抑制作用。在这四种抑制剂中，PPP和DPP对PGE1表现出相对选择性拮抗作用。DPP对PGE1的pW2值最高。这些结果表明，DPP是平滑肌中PG的有效拮抗剂，尽管它对ACh、5 - HT或组胺的反应以及钾去极化制剂中钙诱导的挛缩有轻微抑制作用。