Venge P, Zetterström O, Dahl R, Roxin L E, Olsson I
Lancet. 1977 Aug 20;2(8034):373-5. doi: 10.1016/s0140-6736(77)90303-8.
Arginine-rich cationic proteins are a major constituent of the granules of eosinophil leucocytes. In healthy individuals, serum levels of cationic proteins were correlated with blood eosinophil-counts. In asthma patients blood eosinophil-counts were raised but serum cationic-protein levels were lower than expected. Some patients with intrinsic asthma had very low cationic-protein levels despite high eosinophilia. A challenge test in one patient caused a striking decrease in serum cationic proteins but no change in eosinophil-count. Assays of serum "eosinophil" cationic proteins may be useful in the differentiation of atopic and intrinsic asthma and may throw light on pathogenesis.
富含精氨酸的阳离子蛋白是嗜酸性粒细胞颗粒的主要成分。在健康个体中，阳离子蛋白的血清水平与血液嗜酸性粒细胞计数相关。哮喘患者的血液嗜酸性粒细胞计数升高，但血清阳离子蛋白水平低于预期。一些内源性哮喘患者尽管嗜酸性粒细胞增多，但阳离子蛋白水平却非常低。对一名患者进行的激发试验导致血清阳离子蛋白显著下降，但嗜酸性粒细胞计数没有变化。血清“嗜酸性粒细胞”阳离子蛋白检测可能有助于鉴别特应性哮喘和内源性哮喘，并可能有助于揭示发病机制。
