Hiatt R A, Dales L G, Friedman G D, Hunkeler E M
Am J Epidemiol. 1982 Feb;115(2):255-65. doi: 10.1093/oxfordjournals.aje.a113297.
The rate of occurrence of stones of the urinary tract was assessed in a large population served by the Northern California Kaiser Foundation Health Plan. The study involved three separate groups. First, data were obtained by questionnaire from approximately 175,000 adults who took a multiphasic health checkup in the period 1964-1972; of these generally well adult members, 26.2/1000 persons (32.0/1000 men and 21.0/1000 women) reported having ever been told by a physician that they had a urinary tract stone. Second, data were obtained from 139,000 persons served by the San Francisco outpatient facility in 1970-1972; 1.22/1000 per year (1.81/1000 men and 0.59/1000 women) had an initial diagnosis of a "new or recurrent" stone of the upper urinary tract. The third set of data was procured from the entire Northern California region in 1971-1975; 0.36/1000 (0.52/1000 men and 0.19/1000 women) were discharged from a hospital each year with a diagnosis of upper urinary tract stone. All rates were age-adjusted to the 1960 US Census population. Of these three rates, the rate derived from the outpatient visit record most closely estimates incidence, since nearly all persons who are hospitalized are first seen as outpatients. Rates of kidney stone diagnosis were three times more common in men and, although rare before 20 years of age, the frequency increased rapidly and peaked in the age group 40 to 59 years. Rates were approximately twice as high in whites as in blacks and Orientals; the frequency of stones was inversely related to socioeconomic status as measured by level of education. Over 90% of stones occurred in the upper urinary tract, and the majority contained calcium oxalate. Population-based rates of occurrence of kidney stones are not generally available in the United States. Comparisons with the few available studies indicate that rates in the Kaiser Foundation Health Plan population may be high.
在北加利福尼亚凯撒基金会健康计划所服务的大量人群中,对尿路结石的发生率进行了评估。该研究涉及三个独立的群体。首先,通过问卷调查从1964年至1972年期间进行多阶段健康检查的约175,000名成年人中获取数据;在这些总体健康的成年成员中,每1000人中有26.2人(每1000名男性中有32.0人,每1000名女性中有21.0人)报告曾被医生告知患有尿路结石。其次,从1970年至1972年期间旧金山门诊设施所服务的139,000人中获取数据;每年每1000人中有1.22人(每1000名男性中有1.81人,每1000名女性中有0.59人)被初步诊断为上尿路“新发或复发性”结石。第三组数据是从1971年至1975年整个北加利福尼亚地区获取的;每年每1000人中有0.36人(每1000名男性中有0.52人,每1000名女性中有0.19人)因上尿路结石诊断而从医院出院。所有发病率均根据1960年美国人口普查数据进行了年龄调整。在这三个发病率中,来自门诊就诊记录的发病率最接近估计发病率,因为几乎所有住院患者最初都是作为门诊患者就诊的。肾结石诊断率在男性中是女性的三倍,并且尽管在20岁之前很少见,但发病率迅速上升,并在40至59岁年龄组达到峰值。白人中的发病率约为黑人和东方人的两倍;结石的发病率与以教育水平衡量的社会经济地位呈负相关。超过90%的结石发生在上尿路,并且大多数含有草酸钙。在美国,一般没有基于人群的肾结石发病率数据。与少数现有研究的比较表明,凯撒基金会健康计划人群中的发病率可能较高。