Popat N, Wood W G, Weatherall D J, Turnbull A C
Lancet. 1977 Aug 20;2(8034):377-9. doi: 10.1016/s0140-6736(77)90305-1.
Maternal haemoglobin F production has been monitored in 11 normal pregnancies, with an immunofluorescent technique. In all cases there was a significant increase in the number of F-cells which reached a peak at 18-22 weeks' gestation. Comparison of the numbers of F-cells with the percentage haemoglobin F determined chemically indicated that the increase in maternal haemoglobin F synthesis results from an increased production of F-cells rather than from an increased synthesis of haemoglobin F by the F-cells. There was a highly significant increase in the number of F-cells in a pregnant beta-thalassaemia heterozygote.
采用免疫荧光技术对11例正常妊娠孕妇的母体血红蛋白F生成情况进行了监测。在所有病例中，F细胞数量均显著增加，并在妊娠18 - 22周时达到峰值。将F细胞数量与化学测定的血红蛋白F百分比进行比较表明，母体血红蛋白F合成的增加是由于F细胞生成增加，而非F细胞内血红蛋白F合成增加所致。一名β地中海贫血杂合子孕妇的F细胞数量有极显著增加。
