del Rey A, Besedovsky H O, Sorkin E, Da Prada M, Bondiolotti G P
Am J Physiol. 1982 Jan;242(1):R30-3. doi: 10.1152/ajpregu.1982.242.1.R30.
A quantitative relationship is reported between the magnitude of the immune response of rats to sheep red blood cells and diminution of splenic norepinephrine (NE). A decrease in concentration and content of NE in the spleen on day 3 after immunization was evident in both high- and low-responder animals, whereas a diminished concentration of NE persisted only in the high responders. This continuing NE diminution in high-responder animals is associated with increase in spleen weight, probably attributable to blood accumulation. These findings are consonant with the concept that the sympathetic nervous system is involved in immunoregulation.
据报道，大鼠对绵羊红细胞免疫反应的强度与脾脏去甲肾上腺素（NE）的减少之间存在定量关系。在高反应性和低反应性动物中，免疫后第3天脾脏中NE的浓度和含量均明显降低，而NE浓度的降低仅在高反应性动物中持续存在。高反应性动物中NE的持续减少与脾脏重量增加有关，这可能归因于血液积聚。这些发现与交感神经系统参与免疫调节的概念一致。
