Smythe W R, Alfrey A C, Craswell P W, Crouch C A, Ibels L S, Kubo H, Nunnelley L L, Rudolph H
Ann Intern Med. 1982 Mar;96(3):302-10. doi: 10.7326/0003-4819-96-3-302.
We studied the elemental composition of autopsy tissue samples to characterize the trace element changes induced in various human tissues by uremia. Samples from the United States and Australia, including those from 120 uremic patients who had been on dialysis, 29 uremic patients who had not been on dialysis, and 64 control subjects, were analyzed by x-ray fluorescence. Tissues analyzed were aorta, bone, brain, heart, kidney, liver, lung, muscle, and spleen; elements measured included potassium, calcium, iron, copper, zinc, selenium, bromine, rubidium, strontium, molybdenum, cadmium, tin, and uranium. Uremic abnormalities that were statistically very significant were found, including increases of calcium, strontium, molybdenum, cadmium, and tin and decreases of potassium and rubidium. The distribution of iron, copper, and zinc are altered. We conclude that these abnormalities are primarily the result of the uremia and that, generally, they are neither greatly moderated nor exacerbated by the dialysis procedure.
我们研究了尸检组织样本的元素组成，以表征尿毒症在各种人体组织中引起的微量元素变化。对来自美国和澳大利亚的样本进行了X射线荧光分析，这些样本包括120名接受透析的尿毒症患者、29名未接受透析的尿毒症患者以及64名对照受试者的样本。分析的组织包括主动脉、骨骼、大脑、心脏、肾脏、肝脏、肺、肌肉和脾脏；测量的元素包括钾、钙、铁、铜、锌、硒、溴、铷、锶、钼、镉、锡和铀。发现了具有统计学显著意义的尿毒症异常情况，包括钙、锶、钼、镉和锡增加，钾和铷减少。铁、铜和锌的分布发生了改变。我们得出结论，这些异常主要是尿毒症的结果，并且一般来说，透析程序既不会使其大幅缓解，也不会使其加剧。
