Hammond W P, Adamson J W, Dale D C
Br J Haematol. 1982 Feb;50(2):283-94. doi: 10.1111/j.1365-2141.1982.tb01918.x.
We have examined the effects of chronic endotoxin treatment on erythropoiesis in six grey collies with cyclic haematopoiesis. Blood reticulocytes, bone marrow erythroid colony (EC) forming cells, serum iron and erythropoietin (ESF) values showed regular periodic fluctuations in untreated grey collies. Daily endotoxin injections eliminated the cyclic fluctuations of reticulocytes and EC. The mean serum iron values were increased and recurrent hypoferraemia eliminated, while the mean serum ESF values were reduced. The cyclic fluctuations of serum ESF values were no longer apparent in the endotoxin treated grey collies. Tritiated thymidine suicide of the marrow EC forming cells failed to show cyclic changes either in untreated or endotoxin treated dogs. The ESF sensitivity of EC in the grey collie was unchanged during endotoxin treatment and was not different from normal dogs. Endotoxin appears to alter periodic erythropoiesis by stabilizing the flux of cells into the committed erythroid precursor cell pool from a more primitive stem cell compartment.
我们研究了慢性内毒素处理对六只患有周期性造血的灰色柯利犬红细胞生成的影响。在未经处理的灰色柯利犬中，血液网织红细胞、骨髓红系集落（EC）形成细胞、血清铁和促红细胞生成素（ESF）值呈现出规律性的周期性波动。每日注射内毒素消除了网织红细胞和EC的周期性波动。血清铁平均值升高，反复出现的低铁血症消除，而血清ESF平均值降低。在内毒素处理的灰色柯利犬中，血清ESF值的周期性波动不再明显。无论是未经处理还是经内毒素处理的犬，骨髓EC形成细胞的氚标记胸腺嘧啶自杀法均未显示出周期性变化。在内毒素处理期间，灰色柯利犬中EC对ESF的敏感性未改变，且与正常犬无差异。内毒素似乎通过稳定细胞从更原始的干细胞区室流入定向红系前体细胞池的通量来改变周期性红细胞生成。
