Small W C, Goldstein J H
Biochim Biophys Acta. 1982 Feb 10;720(1):81-6. doi: 10.1016/0167-4889(82)90041-6.
The response of human red blood cells to the cryoprotective agents, DMSO and glycerol, has been investigated using a pulsed NMR method. The experimentally determined parameters are: (1) the intracellular transverse relaxation time, T2a; (2) the mean residence time of intracellular water, tau a, which is effectively a reciprocal measure of the rate of water transport across the red blood cell membrane; and (3) the activation energy for this process. The quantitative data indicate that the observed effects are colligative rather than species-specific in origin.
