Cole W C, LeBlanc A D, Jhingran S G
Methodist Hospital, Department of Nuclear Medicine, Houston, TX 77030.
Magn Reson Med. 1993 Jan;29(1):19-24. doi: 10.1002/mrm.1910290106.
Two theories have been proposed to explain the multiexponential transverse relaxation of muscle water protons: "anatomical" and "chemical" compartmentation. In an attempt to obtain evidence to support one or the other of these two theories, interstitial and intracellular macromolecular preparations were studied and compared with rat muscle tissue by proton NMR transverse relaxation (T2) measurements. All macromolecule preparations displayed monoexponential T2 decay. Membrane alteration with DMSO/glycerin did not eliminate the biexponential T2 decay of muscle tissue. Maceration converted biexponential T2 decay of muscle tissue to single exponential decay. It is concluded that the observed two component exponential T2 decay of muscle represents anatomical compartmentation of tissue water, probably intracellular versus extracellular.
为解释肌肉水质子的多指数横向弛豫，已提出两种理论：“解剖学”和“化学”分隔。为获取证据支持这两种理论中的一种，通过质子核磁共振横向弛豫（T2）测量，对细胞间质和细胞内大分子制剂进行了研究，并与大鼠肌肉组织进行了比较。所有大分子制剂均呈现单指数T2衰减。用二甲基亚砜/甘油进行的膜改变并未消除肌肉组织的双指数T2衰减。浸渍使肌肉组织的双指数T2衰减转变为单指数衰减。得出的结论是，观察到的肌肉双组分指数T2衰减代表组织水的解剖学分隔，可能是细胞内与细胞外的分隔。
