Perzin K H, Bridge M F
Cancer. 1982 Mar 1;49(5):971-83. doi: 10.1002/1097-0142(19820301)49:5<971::aid-cncr2820490522>3.0.co;2-1.
The authors report the unique case of a patient with the Peutz-Jeghers (P-J) syndrome who had multiple small bowel hamartomatous polyps, some of which also showed adenomatous and carcinomatous changes. Over the course of 30 years, over 100 small bowel and colonic polyps were resected; all histologically demonstrated the typical features seen in hamartomatous polyps. Several jejunoileal polyps excised during the last few months of the patient's life showed not only hamartomatous features but also adenomatous epithelium. As far as the authors can determine, this is the first documented case of adenomatous changes found within a small bowel hamartomatous polyp. In addition, at least one duodenal polyp demonstrated areas of hamartoma, adenoma, and in situ carcinoma. The literature on the occurrence of gastrointestinal adenomas and carcinomas in patients with the P-J syndrome is reviewed, and the relationship of hamartomas, adenomas, and carcinomas of the gastrointestinal tract is discussed.
作者报告了一例患有佩-吉（Peutz-Jeghers，P-J）综合征的患者的独特病例，该患者有多个小肠错构瘤性息肉，其中一些还表现出腺瘤性和癌性改变。在30年的病程中，切除了100多个小肠和结肠息肉；所有息肉在组织学上均显示出错构瘤性息肉的典型特征。在患者生命的最后几个月切除的几个空肠回肠息肉不仅表现出错构瘤特征，还出现了腺瘤性上皮。据作者所知，这是首次记录到小肠错构瘤性息肉内出现腺瘤性改变的病例。此外，至少有一个十二指肠息肉显示出错构瘤、腺瘤和原位癌区域。本文回顾了有关P-J综合征患者胃肠道腺瘤和癌发生情况的文献，并讨论了胃肠道错构瘤、腺瘤和癌之间的关系。
