12-O-十四烷酰佛波醇-13-乙酸酯和芫花酯甲对静止牛淋巴细胞中γ辐射诱导的DNA修复的影响。

Effects of 12-O-tetradecanoylphorbol-13-acetate and mezerein on gamma radiation-induced DNA repair in resting bovine lymphocytes.

作者信息

Perrella F W, O'Leary P, Boutwell R K

出版信息

Cancer Lett. 1982 Jan;15(1):87-93. doi: 10.1016/0304-3835(82)90080-5.

Abstract

The present study was undertaken to determine the effect of the potent tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) on gamma radiation-induced DNA repair in resting (Go) lymphocytes. Mezerein, a non-promoter but a co-mitogen in lymphocytes, was used as a control agent. It was previously proposed that a possible mechanism for the action of tumor promoters was through the inhibition of DNA repair processes. Our results indicate that TPA does not inhibit DNA repair following gamma irradiation of Go lymphocytes. These data support the hypothesis that the tumor promoting ability of TPA is not a result of impaired repair of potentially mutagenic lesions in DNA.

摘要

本研究旨在确定强效肿瘤促进剂12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯（TPA）对静止（G0）淋巴细胞中γ射线诱导的DNA修复的影响。芫花酯甲是一种非促进剂但在淋巴细胞中是共促有丝分裂原，用作对照剂。先前有人提出肿瘤促进剂作用的一种可能机制是通过抑制DNA修复过程。我们的结果表明，TPA不会抑制G0淋巴细胞γ射线照射后的DNA修复。这些数据支持了以下假设：TPA的肿瘤促进能力不是DNA中潜在诱变损伤修复受损的结果。