Shea M J, Bush L R, Romson J L, Driscoll E M, Lucchesi B R
Eur J Pharmacol. 1982 Jan 8;77(1):67-70. doi: 10.1016/0014-2999(82)90538-6.
The effect of diltiazem vs. saline was studied in a conscious canine model of coronary thrombosis. Diltiazem given as a 0.75 mg/kg loading dose intravenously followed by 0.4 mg/kg intravenously every 4 h for 24 h had no significant effect on thrombus wet weight, left ventricular infarct size, frequency of ventricular arrhythmias or ex vivo platelet aggregation. The search for antithrombotic agents using in vitro or ex vivo platelet aggregation studies should include concomitant in vivo thrombosis studies using therapeutic dosages of the drug in question.
在清醒犬冠状动脉血栓形成模型中研究了地尔硫䓬与生理盐水的效果。静脉给予0.75mg/kg负荷剂量的地尔硫䓬，随后每4小时静脉给予0.4mg/kg，持续24小时，对血栓湿重、左心室梗死面积、室性心律失常频率或体外血小板聚集均无显著影响。使用体外或体外血小板聚集研究寻找抗血栓药物时，应包括使用相关药物治疗剂量的体内血栓形成研究。
