Wolf N S
Exp Hematol. 1982 Jan;10(1):98-107.
A chronologic study was made of whole organ necrosis and subsequent regeneration in the pedicle ligated mouse spleen. The whole organ necrosis involved all but a thin layer of cells including and beneath the splenic capsule. Cellular regeneration issued from these surviving cells and was seen to proceed inward along remaining noncellular reticular fiber tracts throughout the spleen, resulting in complete architectural restoration. Destruction of these fibers resulted in failure of orderly reconstruction of splenic substance. A subcapsular vascular space was made prominent by the ligation and appeared to completely circumscribe the internal splenic substance. Regeneration appeared to begin with cells just central to this space. Reconstruction of the ligated spleen was architecturally complete within 40 days.
对蒂结扎小鼠脾脏的全器官坏死及随后的再生进行了一项时间顺序研究。全器官坏死累及除脾包膜及其下方一薄层细胞外的所有细胞。细胞再生由这些存活细胞发出，可见其沿着脾脏内剩余的无细胞网状纤维束向内推进，导致结构完全恢复。这些纤维的破坏导致脾实质无法有序重建。结扎使包膜下血管间隙突出，似乎完全包围了脾脏内部实质。再生似乎从该间隙正中央的细胞开始。结扎脾脏的结构在40天内完全重建。
