Vierhapper H, Grubeck-Loebenstein B, Korn A, Waldhäusl W
Hypertension. 1982 Jan-Feb;4(1):112-7. doi: 10.1161/01.hyp.4.1.112.
To assess the effect of prostaglandin inhibition upon the vasoactive actions of endogenous and exogenous catecholamines in healthy man, indomethacin (150 mg/day for 3 days) was administered to six healthy men in the sodium-repleted state. Pretreatment with indomethacin did not interfere with the response of blood pressure and pulse rate to orthostasis (10 minutes), a cold pressor test (2 minutes), and the intravenous (i.v.) administration of norepinephrine (NE) (50, 100, and 200 ng kg-1 min-1). Basal plasma concentrations of epinephrine (E) and NE as well as the concentrations of E during orthostasis and cold pressor test remained uninfluenced by pretreatment with indomethacin. While the release of NE during orthostasis appeared to be suppressed in the indomethacin-treated state, it was unchanged during the cold pressor test. These results indicate that inhibition of endogenous prostaglandin synthesis may suppress the release of NE, but does not have a major impact on the vasoactive actions of endogenous and exogenous catecholamines in normal men.
为评估前列腺素抑制对内源性和外源性儿茶酚胺在健康男性体内血管活性作用的影响，对6名处于钠补充状态的健康男性给予吲哚美辛（150毫克/天，共3天）。吲哚美辛预处理不影响血压和脉率对直立位（10分钟）、冷加压试验（2分钟）以及静脉注射去甲肾上腺素（NE）（50、100和200纳克/千克-1分钟-1）的反应。基础血浆肾上腺素（E）和NE浓度以及直立位和冷加压试验期间的E浓度不受吲哚美辛预处理的影响。虽然在吲哚美辛处理状态下直立位期间NE的释放似乎受到抑制，但在冷加压试验期间其未发生变化。这些结果表明，内源性前列腺素合成的抑制可能会抑制NE的释放，但对正常男性体内内源性和外源性儿茶酚胺的血管活性作用没有重大影响。
