Rubin P, Blaschke T
Prostaglandins. 1979 Apr;17(4):581-5. doi: 10.1016/0090-6980(79)90009-1.
Indomethacin has been reported to potentiate the release of noradrenaline from sympathetic nerve endings in vitro and to increase urinary noradrenaline excretion in rats. We have studied the influence of indomethacin on plasma catecholamine levels in 10 normal men, using measurement of plasma renin activity (PRA) as an index of the pharmacodynamic effect of indomethacin. Both in the supine and standing positions indomethacin failed to alter the plasma concentrations of noradrenaline, adrenaline or dopamine, while PRA was markedly suppressed. It is concluded that in the intact human indomethacin does not influence catecholamine concentrations.
据报道，吲哚美辛在体外可增强交感神经末梢去甲肾上腺素的释放，并增加大鼠尿中去甲肾上腺素的排泄。我们以血浆肾素活性（PRA）作为吲哚美辛药效学效应的指标，研究了吲哚美辛对10名正常男性血浆儿茶酚胺水平的影响。无论在仰卧位还是站立位，吲哚美辛均未能改变去甲肾上腺素、肾上腺素或多巴胺的血浆浓度，而PRA则明显受到抑制。结论是，在完整的人体中，吲哚美辛不影响儿茶酚胺浓度。
