Ra3皮肤试验反应与HLA - A2、抗原E和IgE：抗原E与HLA之间相互作用的证据

Ra3 skin test response and HLA-A2, antigen E, and IgE: evidence of interactions between antigen E and HLA.

作者信息

Mendell N R, Amos D B, Blumenthal M N, Gleich G J, Yunis E J

出版信息

Hum Immunol. 1982 Feb;4(1):63-70. doi: 10.1016/0198-8859(82)90051-9.

Abstract

A positive association of Ra3 skin test responses with HLA-A2 has previously been reported to be evident in individuals with low IgE levels and to a greater extent in these individuals than those with high IgE levels. We give evidence based on an analysis of data from 133 individuals that Ra3 response is positively correlated with HLA-A2 among individuals with low Antigen E response and negatively associated with HLA-A2 among individuals with high Antigen E response. Furthermore, we have evidence that any observed interaction between Ra3, IgE, and HLA-A2 can be explained by the correlation between IgE and Antigen E response, and that it is Antigen E response which interacts in the relationship between HLA-A2 and Ra3 skin test response.

摘要

先前有报道称，Ra3皮肤试验反应与HLA - A2呈正相关，在低IgE水平个体中明显，且在这些个体中比高IgE水平个体的相关性更强。我们基于对133名个体数据的分析给出证据，在低抗原E反应个体中，Ra3反应与HLA - A2呈正相关，而在高抗原E反应个体中，Ra3反应与HLA - A2呈负相关。此外，我们有证据表明，观察到的Ra3、IgE和HLA - A2之间的任何相互作用都可以由IgE与抗原E反应之间的相关性来解释，并且在HLA - A2与Ra3皮肤试验反应的关系中起相互作用的是抗原E反应。