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相似文献

1
Effect of the active tumor promoter, 12-O-tetradecanoylphorbol-13-acetate on hair follicular growth and development of hair anlage tumors in the mouse skin: a comparison with human adnexal lesions.活性肿瘤启动子12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯对小鼠皮肤毛囊生长及毛囊肿瘤发生发展的影响：与人类附属器病变的比较
J Cancer Res Clin Oncol. 1982;102(3):245-52. doi: 10.1007/BF00411344.
2
12-0-Tetradecanoylphorbol-13-acetate-induced amplification of mesenchymal tumorigenesis in the mouse skin.12-0-十四酰佛波醇-13-乙酸酯诱导小鼠皮肤间充质肿瘤发生的扩增。
J Cancer Res Clin Oncol. 1983;105(1):48-54. doi: 10.1007/BF00391831.
3
Induction of the formation of new hair follicles in mouse tail epidermis by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.肿瘤促进剂12-O-十四酰佛波醇-13-乙酸酯诱导小鼠尾部表皮新毛囊形成
Cancer Res. 1977 Nov;37(11):4195-201.
4
Two-stage skin carcinogenesis by systemic initiation of pregnant mice with 7,12-dimethylbenz(a)anthracene during gestation days 6-20 and postnatal promotion of the F 1-generation with the phorbol ester 12-tetradecanoylphorbol-13-acetate.通过在妊娠第6至20天用7,12 - 二甲基苯并(a)蒽对怀孕小鼠进行全身启动，并在F1代出生后用佛波酯12 - 十四酰佛波醇-13 - 乙酸酯进行促进，诱导两阶段皮肤癌发生。
J Cancer Res Clin Oncol. 1980;98(3):267-75. doi: 10.1007/BF00410789.
5
Differential effects of phorbol ester tumor promoters on 3-methylcholanthrene-induced epithelial and mesenchymal skin tumorigenesis.佛波酯肿瘤启动子对3-甲基胆蒽诱导的上皮性和间质性皮肤肿瘤发生的差异效应。
J Cancer Res Clin Oncol. 1988;114(3):279-82. doi: 10.1007/BF00405834.
6
Thapsigargin, a histamine secretagogue, is a non-12-O-tetradecanoylphorbol-13-acetate (TPA) type tumor promoter in two-stage mouse skin carcinogenesis.毒胡萝卜素是一种组胺促分泌剂，在小鼠皮肤两阶段致癌过程中是一种非12 - O -十四烷酰佛波醇-13 -乙酸酯（TPA）型肿瘤促进剂。
J Cancer Res Clin Oncol. 1986;111(3):177-81. doi: 10.1007/BF00389230.
7
Effect of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and its nonpromoting analogue 4-O-methyl-TPA on dorsal dermal melanocytes of the Syrian golden hamster (Mesocricetus auratus).肿瘤促进剂12-O-十四烷酰佛波醇-13-乙酸酯及其非促进类似物4-O-甲基佛波醇-13-乙酸酯对叙利亚金黄地鼠（金仓鼠）背部真皮黑素细胞的影响。
J Cancer Res Clin Oncol. 1982;103(3):305-11. doi: 10.1007/BF00409706.
8
Early epidermal destruction with subsequent epidermal hyperplasia is a unique feature of the papilloma-independent squamous cell carcinoma phenotype in PKCepsilon overexpressing transgenic mice.早期表皮破坏并随后出现表皮增生是蛋白激酶Cε过表达转基因小鼠中不依赖乳头瘤的鳞状细胞癌表型的独特特征。
Toxicol Pathol. 2005;33(6):684-94. doi: 10.1080/01926230500323441.
9
Cutaneous changes during prolonged application of 12-O-tetradecanoylphorbol-13-acetate on mouse skin and residual effects after cessation of treatment.12 - O - 十四酰佛波醇 - 13 - 乙酸酯长期涂抹于小鼠皮肤期间的皮肤变化及停药后的残留效应。
Cancer Res. 1985 Jun;45(6):2753-9.
10
Biological assays for irritant, tumor-initiating and tumor-promoting activities. II. Standardized initiation/promotion protocol and semiquantitative estimation of promoting (or initiating) potencies in skin of NMRI mice.刺激性、肿瘤启动和肿瘤促进活性的生物学测定。II. 标准化的启动/促进方案以及NMRI小鼠皮肤中促进（或启动）效力的半定量评估。
J Cancer Res Clin Oncol. 1989;115(6):516-24. doi: 10.1007/BF00391351.

引用本文的文献

1
Follicular origin of epidermal papillomas in v-Ha-ras transgenic TG.AC mouse skin.v-Ha-ras转基因TG.AC小鼠皮肤中表皮乳头状瘤的毛囊起源
Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7822-6. doi: 10.1073/pnas.91.16.7822.
2
Skin-specific expression of a truncated E1a oncoprotein binding to p105-Rb leads to abnormal hair follicle maturation without increased epidermal proliferation.与p105-Rb结合的截短型E1a癌蛋白在皮肤中的特异性表达导致毛囊成熟异常，而表皮增殖未增加。
J Cell Biol. 1993 Jun;121(5):1109-20. doi: 10.1083/jcb.121.5.1109.
3
Differential effects of phorbol ester tumor promoters on 3-methylcholanthrene-induced epithelial and mesenchymal skin tumorigenesis.佛波酯肿瘤启动子对3-甲基胆蒽诱导的上皮性和间质性皮肤肿瘤发生的差异效应。
J Cancer Res Clin Oncol. 1988;114(3):279-82. doi: 10.1007/BF00405834.

本文引用的文献

1
Action of methylcholanthrene on certain scars of the skin in mice.甲基胆蒽对小鼠皮肤某些瘢痕的作用。
Cancer Res. 1946 Apr;6:183-8.
2
The role of the hair follicle in the origin and evolution of some cutaneous neoplasms of man and experimental animals.毛囊在人类和实验动物某些皮肤肿瘤的起源与演变中的作用。
Cancer. 1961 Jul-Aug;14:801-16. doi: 10.1002/1097-0142(199007/08)14:4<801::aid-cncr2820140417>3.0.co;2-k.
3
An experimental analysis of the hair cycle effect in mouse skin carcinogenesis.小鼠皮肤癌发生过程中毛发周期效应的实验分析。
Br J Cancer. 1958 Sep;12(3):402-13. doi: 10.1038/bjc.1958.48.
4
Tumor-promoting activity of phorbol and four diesters of phorbol in mouse skin.佛波醇及其四种二酯在小鼠皮肤中的促肿瘤活性。
Cancer Res. 1971 Aug;31(8):1074-9.
5
Early effects of 12-O-tetradecanoyl-phorbol-13-acetate on the incorporation of tritiated precursor into DNA and the thickness of the interfollicular epidermis, and their relation to tumor promotion in mouse skin.12-O-十四烷酰佛波醇-13-乙酸酯对氚标记前体掺入DNA及毛囊间表皮厚度的早期影响及其与小鼠皮肤肿瘤促进作用的关系。
Cancer Res. 1972 Jul;32(7):1562-8.
6
Ultrastructural, histological, and biochemical alterations produced by 12-O-tetradecanoyl-phorbol-13-acetate on mouse epidermis and their relevance to skin tumor promotion.12-O-十四烷酰佛波醇-13-乙酸酯对小鼠表皮产生的超微结构、组织学及生化改变及其与皮肤肿瘤促进作用的相关性
Cancer Res. 1973 Feb;33(2):269-86.
7
The sensitivity of the skin of hairless mice to chemical carcinogenesis.无毛小鼠皮肤对化学致癌作用的敏感性。
Cancer Res. 1976 Apr;36(4):1238-41.
8
Selective promoting activity of phorbol myristate acetate in experimental skin carcinogenesis.佛波醇肉豆蔻酸酯乙酸酯在实验性皮肤癌发生中的选择性促进活性。
Br J Cancer. 1976 Dec;34(6):661-5. doi: 10.1038/bjc.1976.229.
9
Induction of the formation of new hair follicles in mouse tail epidermis by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.肿瘤促进剂12-O-十四酰佛波醇-13-乙酸酯诱导小鼠尾部表皮新毛囊形成
Cancer Res. 1977 Nov;37(11):4195-201.

活性肿瘤启动子12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯对小鼠皮肤毛囊生长及毛囊肿瘤发生发展的影响：与人类附属器病变的比较

Effect of the active tumor promoter, 12-O-tetradecanoylphorbol-13-acetate on hair follicular growth and development of hair anlage tumors in the mouse skin: a comparison with human adnexal lesions.

作者信息

Bhisey R A, Iyengar B, Sirsat S M

出版信息

J Cancer Res Clin Oncol. 1982;102(3):245-52. doi: 10.1007/BF00411344.

DOI:10.1007/BF00411344
PMID:7061571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12252754/
Abstract

Effect of the active tumor promoter, TPA, on the induction of hair follicular growth and possible neoplasia was studied histologically in normal nd precancerous mouse skin. Biweekly application of TPA resulted in nevoid proliferation of hair follicles, decreased the latent period of tumor induction, and increased the number of carcinomas of hair follicular origin in mice pretreated with MCA. The experimental tumor induction data was compared with human adnexal tumors of hair follicular origin. Similar types of animal and human lesions could be attributed to the promoter effect alone or to the dual influence of a carcinogen and promoter.

摘要

在正常和癌前小鼠皮肤中，通过组织学方法研究了活性肿瘤启动子佛波酯（TPA）对毛囊生长诱导及可能的肿瘤形成的影响。每两周应用一次TPA导致毛囊出现痣样增生，缩短了肿瘤诱导的潜伏期，并增加了经甲基胆蒽（MCA）预处理的小鼠毛囊源性癌的数量。将实验性肿瘤诱导数据与人类毛囊源性附属器肿瘤进行了比较。相似类型的动物和人类病变可能仅归因于启动子效应，或归因于致癌物和启动子的双重影响。