活性肿瘤启动子12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯对小鼠皮肤毛囊生长及毛囊肿瘤发生发展的影响：与人类附属器病变的比较
Effect of the active tumor promoter, 12-O-tetradecanoylphorbol-13-acetate on hair follicular growth and development of hair anlage tumors in the mouse skin: a comparison with human adnexal lesions.
作者信息
Bhisey R A, Iyengar B, Sirsat S M
出版信息
J Cancer Res Clin Oncol. 1982;102(3):245-52. doi: 10.1007/BF00411344.
Abstract
Effect of the active tumor promoter, TPA, on the induction of hair follicular growth and possible neoplasia was studied histologically in normal nd precancerous mouse skin. Biweekly application of TPA resulted in nevoid proliferation of hair follicles, decreased the latent period of tumor induction, and increased the number of carcinomas of hair follicular origin in mice pretreated with MCA. The experimental tumor induction data was compared with human adnexal tumors of hair follicular origin. Similar types of animal and human lesions could be attributed to the promoter effect alone or to the dual influence of a carcinogen and promoter.
摘要
在正常和癌前小鼠皮肤中，通过组织学方法研究了活性肿瘤启动子佛波酯（TPA）对毛囊生长诱导及可能的肿瘤形成的影响。每两周应用一次TPA导致毛囊出现痣样增生，缩短了肿瘤诱导的潜伏期，并增加了经甲基胆蒽（MCA）预处理的小鼠毛囊源性癌的数量。将实验性肿瘤诱导数据与人类毛囊源性附属器肿瘤进行了比较。相似类型的动物和人类病变可能仅归因于启动子效应，或归因于致癌物和启动子的双重影响。
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Effect of the active tumor promoter, 12-O-tetradecanoylphorbol-13-acetate on hair follicular growth and development of hair anlage tumors in the mouse skin: a comparison with human adnexal lesions.活性肿瘤启动子12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯对小鼠皮肤毛囊生长及毛囊肿瘤发生发展的影响：与人类附属器病变的比较
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Action of methylcholanthrene on certain scars of the skin in mice.甲基胆蒽对小鼠皮肤某些瘢痕的作用。
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Early effects of 12-O-tetradecanoyl-phorbol-13-acetate on the incorporation of tritiated precursor into DNA and the thickness of the interfollicular epidermis, and their relation to tumor promotion in mouse skin.12-O-十四烷酰佛波醇-13-乙酸酯对氚标记前体掺入DNA及毛囊间表皮厚度的早期影响及其与小鼠皮肤肿瘤促进作用的关系。
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Selective promoting activity of phorbol myristate acetate in experimental skin carcinogenesis.佛波醇肉豆蔻酸酯乙酸酯在实验性皮肤癌发生中的选择性促进活性。
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