Prier S, Larmande P, Henin D, Delouvrier J J, Masson M
J Fr Ophtalmol. 1982;5(1):49-53.
Five cases of Fischer's "one and a half" syndrome are reported. A complex central ophthalmoplegia provokes paralysis of horizontal eye movements on the affected side in both eyes and an internuclear ophthalmoplegia on the same side. No horizontal movement, except in convergence, is possible in the eye on the affected side, the other eye exhibiting movement between the median line and abduction only. Three patients with this syndrome were examined by oculography. The outcome was fatal in one case, pathological examination demonstrating widespread damage to half the pontine protuberance. In another case scanner imaging showed a paramedian protuberential lesion. The syndrome is most frequently observed in multiple sclerosis and cerebrovascular accidents but may follow any lesion in this region. Physiopathological features of the disorder are discussed.
本文报告了5例菲舍尔“一个半”综合征病例。复杂的中枢性眼肌麻痹导致双眼患侧水平眼球运动麻痹及同侧核间性眼肌麻痹。患侧眼球除了集合运动外，无法进行水平运动，而另一只眼仅在中线与外展之间有运动。对3例该综合征患者进行了眼球运动描记检查。1例患者预后死亡，病理检查显示脑桥隆起部一半广泛受损。在另一例中，扫描成像显示脑桥旁正中病变。该综合征最常见于多发性硬化症和脑血管意外，但也可能继发于该区域的任何病变。文中讨论了该疾病的生理病理特征。
