Ishihara M, Ito Y, Nakakita T, Maehama T, Hieda S, Yamamoto K, Ueno N
Nihon Sanka Fujinka Gakkai Zasshi. 1982 Feb;34(2):243-51.
Though gamma-Oryzanol has been applicated as the autonomic agent in various fields for a few decades, recently its effect on lipid metabolism comes to be much more interested. We studied on the effect of gamma-Oryzanol on climacteric disturbance, and besides on the difference of lipid peroxides level which has an important and indispensable connection with mary syndromes involving aging. We obtained the following results from 40 subjects with climacteric disturbance after administration of gamma-Oryzanol Fine Particule 1.5 g (gamma-Oryzanol 300 mg included) for 4 to 8 weeks. 1. 90% of the cases improved generally; Excellent 16 (40%), Good 14 (35%), Effective 6 (15%), No change 4 (10%). 2. Effect on climacteric disturbance was judged by the Kupperman method and the Ueda method; generally recovered 85%, 80% each. 3. Significantly reduced total cholesterol, triglyceride and increased HDL-cholesterol were noted in cases with hyperlipidemia (TC greater than or equal to 220 mg/dl, TG greater than or equal to 140 mg/dl, HDL-chol. less than or equal to 45 mg/dl). Therefore, atherogenic index was excellently recovered. 4. In cases with climacteric disturbance lipid peroxides level was high, and they were significantly recovered by administration of gamma-Oryzanol. 5. During this study, no side effects have been recognized and no particular change in function test was found. Thus, we confirmed the efficacy and utility of gamma-Oryzanol on many complaints in climacteric disturbance and also on lipid metabolism.
虽然γ-谷维素作为一种自主剂已在各个领域应用了几十年，但最近它对脂质代谢的影响变得更受关注。我们研究了γ-谷维素对更年期紊乱的影响，此外还研究了与包括衰老在内的许多综合征有着重要且不可或缺联系的脂质过氧化物水平差异。我们对40名患有更年期紊乱的受试者给予γ-谷维素微粒1.5克（含γ-谷维素300毫克），持续4至8周后得出了以下结果。1. 90%的病例总体情况有所改善；优秀16例（40%），良好14例（35%），有效6例（15%），无变化4例（10%）。2. 采用库珀曼法和上田法判断对更年期紊乱的疗效；总体恢复率分别为85%、80%。3. 在高脂血症患者（总胆固醇≥220毫克/分升，甘油三酯≥140毫克/分升，高密度脂蛋白胆固醇≤45毫克/分升）中，总胆固醇、甘油三酯显著降低，高密度脂蛋白胆固醇升高。因此，致动脉粥样化指数得到了很好的恢复。4. 在患有更年期紊乱的病例中，脂质过氧化物水平较高，而服用γ-谷维素后它们显著恢复。5. 在本研究期间，未发现副作用，功能测试也未发现特殊变化。因此，我们证实了γ-谷维素对更年期紊乱的许多症状以及脂质代谢的疗效和实用性。
