Fried W, Barone-Varelas J, Barone T, Anagnostou A
J Lab Clin Med. 1982 Apr;99(4):520-5.
The effects of infusing subpressor doses of angiotensin II into hypoxic and anemic rats on plasma Ep levels were determined. The effect was greatest when 5 micrograms of angiotensin II per hour was infused into rats made hypoxic 18 hr after nephrectomy. Infusion of larger amounts of angiotensin II had a lesser effect on extrarenal Ep production than did infusion of 5 micrograms/hr. Infusion of angiotensin II into rats nephrectomized 1 hr prior to exposure to hypoxia affected extrarenal Ep production to a lesser degree than the infusion into rats nephrectomized 18 hr prior to hypoxia. In contrast, administration of carbon tetrachloride per os stimulated extrarenal Ep production only when nephrectomy was performed just prior to exposure to hypoxia. Administration of both CCl4 and angiotensin II to hypoxic anephric rats elevated the plasma Ep level to approximately 1.0 IRP U/ml.
测定了向缺氧和贫血大鼠输注低于升压剂量的血管紧张素II对血浆肾上腺素（Ep）水平的影响。当每小时向肾切除术后18小时造成缺氧的大鼠输注5微克血管紧张素II时，这种影响最大。与每小时输注5微克相比，输注大量血管紧张素II对肾外Ep产生的影响较小。在缺氧前1小时进行肾切除术的大鼠中输注血管紧张素II，对肾外Ep产生的影响程度小于在缺氧前18小时进行肾切除术的大鼠。相比之下，仅在缺氧前刚进行肾切除术时，经口给予四氯化碳才刺激肾外Ep产生。向缺氧的无肾大鼠同时给予四氯化碳和血管紧张素II，可使血浆Ep水平升高至约1.0国际参考品单位/毫升。
