Lyles J M, Silman I, Di Giamberardino L, Couraud J Y, Barnard E A
J Neurochem. 1982 Apr;38(4):1007-21. doi: 10.1111/j.1471-4159.1982.tb05342.x.
The levels and molecular forms of acetylcholinesterase (AChE, EC 3.1.1.7) and pseudocholinesterase (psiChE, EC 3.1.1.8) were examined in various skeletal muscles, cardiac muscles, and neural tissues from normal and dystrophic chickens. The relative amount of the heavy (Hc) form of AChE in mixed-fibre-type twitch muscles varies in proportion to the percentage of glycolytic fast-twitch fibres. Conversely, muscles with higher levels of oxidative fibres (i.e., slow-tonic oxidative-glycolytic fast-twitch, or oxidative slow-twitch) have higher proportions of the light (L) form of AChE. The effects of dystrophy on AChE and psiChE are more severe in muscles richer in glycolytic fast-twitch fibres (e.g., pectoral or posterior latissimus dorsi, PLD); there is no alteration of AChE or psiChE in a slow-tonic muscle. In the pectoral of PLD muscles from older dystrophic chickens, however, the AChE forms revert to a normal distribution while the pesChE pattern remains abnormal. Muscle psiChE is sensitive to collagenase in a similar way as is AChE, thus apparently having a similar tailed structure. Unlike skeletal muscle, cardiac muscle has very high levels of psiChE, present mainly as the L form; AChE is present mainly as the medium (M) form, with smaller amounts of L and Hc. The latter pattern of AChE forms resembles that seen in several neural tissues examined. No alterations in AChE or psiChE were found in cardiac or neural tissues from dystrophic chickens.
在正常和患营养障碍的鸡的各种骨骼肌、心肌和神经组织中，检测了乙酰胆碱酯酶（AChE，EC 3.1.1.7）和假性胆碱酯酶（psiChE，EC 3.1.1.8）的水平及分子形式。混合纤维类型的快肌中，AChE重（Hc）形式的相对含量与糖酵解型快肌纤维的百分比成比例变化。相反，氧化纤维水平较高的肌肉（即慢张力氧化 - 糖酵解型快肌或氧化型慢肌）中，AChE轻（L）形式的比例更高。营养障碍对AChE和psiChE的影响在富含糖酵解型快肌纤维的肌肉（如胸肌或背阔肌后束，PLD）中更为严重；慢张力肌中的AChE或psiChE没有改变。然而，在老年患营养障碍鸡的胸肌或PLD肌肉中，AChE形式恢复为正常分布，而psiChE模式仍异常。肌肉psiChE对胶原酶的敏感性与AChE相似，因此显然具有类似的尾状结构。与骨骼肌不同，心肌中psiChE水平非常高，主要以L形式存在；AChE主要以中等（M）形式存在，L和Hc形式的含量较少。AChE形式的后一种模式类似于在几种检测的神经组织中看到的模式。在患营养障碍鸡的心脏或神经组织中未发现AChE或psiChE的改变。
