神经元胞体中特异性和非特异性胆碱酯酶活性比率的产后变化。

Postnatal changes in the activity ratio of specific and nonspecific cholinesterases from neuronal perikarya.

作者信息

Ochoa E L, Brusco A, Idoyaga-Vargas V P, Carminatti H

出版信息

J Neurochem. 1982 May;38(5):1236-40. doi: 10.1111/j.1471-4159.1982.tb07896.x.

DOI:10.1111/j.1471-4159.1982.tb07896.x

PMID:7062049

Abstract

A soluble fraction from rat brain neuronal perikarya was shown to contain both the specific and nonspecific forms of the enzyme acetylcholinesterase (EC's 3.1.1.7. and 3.1.1.8., respectively). The ratio of the enzyme activities varied along the course of brain development: the nonspecific form being predominant from 1 to 15 days of age and the specific one showing the pattern of rising activity from day 15 onward. We suggest a possible relationship between this changing in cholinesterase activities and the establishment of synapses within the rat cerebral cortex.

摘要

大鼠脑神经元胞体的可溶性部分被证明含有乙酰胆碱酯酶的特异性和非特异性形式（分别为EC 3.1.1.7和3.1.1.8）。酶活性的比例在脑发育过程中有所变化：非特异性形式在1至15日龄时占主导，而特异性形式从第15天起呈现活性上升的模式。我们提出胆碱酯酶活性的这种变化与大鼠大脑皮质内突触的建立之间可能存在关联。