White D J, Nancollas G H
J Urol. 1982 Mar;127(3):593-7. doi: 10.1016/s0022-5347(17)53919-1.
We investigated the influence of triamterene (TA), and its metabolites parahydroxytriamterene (PHTA), and parahydroxytriamterene sulfate (PHTAS) on the nucleation and crystal growth of calcium oxalate monohydrate (COM), in supersaturated solution at 37C using a new constant composition technique. The spontaneous precipitation of COM is preceded by induction periods which decrease with increasing supersaturation. The addition of the triamterene seed materials substantially reduces there delay periods and induces the crystal growth of COM. Specific surface area and scanning electron microscopic results indicate that the seed materials act as sources for the heterogeneous nucleation of COM. In addition, the surface of the more crystalline PHTAS appears to offer sites from which COM crystals can develop as well formed rosettes. This evidence suggests that in addition to triamterene renal stone formation, TA and its metabolites may catalyze the precipitation of other stone forming minerals with which urines may be supersaturated.
我们采用一种新的恒组成技术，研究了氨苯蝶啶（TA）及其代谢产物对羟基氨苯蝶啶（PHTA）和硫酸对羟基氨苯蝶啶（PHTAS）在37℃过饱和溶液中对一水合草酸钙（COM）成核和晶体生长的影响。COM的自发沉淀之前有诱导期，诱导期随过饱和度增加而缩短。添加氨苯蝶啶籽晶材料可显著缩短延迟期并诱导COM晶体生长。比表面积和扫描电子显微镜结果表明，籽晶材料可作为COM异相成核的来源。此外，结晶度更高的PHTAS表面似乎提供了位点，COM晶体可以从这些位点发育成形态良好的玫瑰花结。这一证据表明，除了氨苯蝶啶导致肾结石形成外，TA及其代谢产物可能催化尿液中可能过饱和的其他结石形成矿物质的沉淀。
