他莫昔芬抗雌激素。他莫昔芬顺式和反式异构体的活性、药代动力学及代谢活化比较。 - Suppr

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超能文献

Tamoxifen antiestrogens. A comparison of the activity, pharmacokinetics, and metabolic activation of the cis and trans isomers of tamoxifen.

作者信息

Robertson D W, Katzenellenbogen J A, Long D J, Rorke E A, Katzenellenbogen B S

出版信息

J Steroid Biochem. 1982 Jan;16(1):1-13. doi: 10.1016/0022-4731(82)90137-6.

DOI:10.1016/0022-4731(82)90137-6

PMID:7062732

Abstract

摘要

相似文献

Tamoxifen antiestrogens. A comparison of the activity, pharmacokinetics, and metabolic activation of the cis and trans isomers of tamoxifen.他莫昔芬抗雌激素。他莫昔芬顺式和反式异构体的活性、药代动力学及代谢活化比较。

J Steroid Biochem. 1982 Jan;16(1):1-13. doi: 10.1016/0022-4731(82)90137-6.

Modulation of rat uterine progesterone receptor levels and peroxidase activity by tamoxifen citrate, LY117018, and estradiol.柠檬酸他莫昔芬、LY117018和雌二醇对大鼠子宫孕酮受体水平及过氧化物酶活性的调节作用

Endocrinology. 1982 Dec;111(6):2046-54. doi: 10.1210/endo-111-6-2046.

Differential antiestrogen action in the immature rat uterus: a comparison of hydroxylated antiestrogens with high affinity for the estrogen receptor.未成熟大鼠子宫中的抗雌激素差异作用：对雌激素受体具有高亲和力的羟基化抗雌激素的比较。

J Steroid Biochem. 1983 Sep;19(3):1249-58. doi: 10.1016/0022-4731(83)90147-4.

Specific binding and biological response of antiestrogens in the fetal uterus of the guinea pig.抗雌激素在豚鼠胎儿子宫中的特异性结合及生物学反应

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Estrogenic stimulation of the antiestrogen specific binding site in rat uterus and liver.雌激素对大鼠子宫和肝脏中抗雌激素特异性结合位点的刺激作用。

Endocrinology. 1983 Jun;112(6):1910-5. doi: 10.1210/endo-112-6-1910.

Effects of hydroxytamoxifen and tamoxifen on peroxidase activity in the immature rat uterus.羟基他莫昔芬和他莫昔芬对未成熟大鼠子宫过氧化物酶活性的影响。

J Steroid Biochem. 1982 Jan;16(1):125-7. doi: 10.1016/0022-4731(82)90153-4.

A new antiestrogen, 2-(4-hydroxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-1H-indol-5-ol hydrochloride (ERA-923), inhibits the growth of tamoxifen-sensitive and -resistant tumors and is devoid of uterotropic effects in mice and rats.一种新型抗雌激素药物，2-(4-羟基苯基)-3-甲基-1-[4-(2-哌啶-1-基乙氧基)苄基]-1H-吲哚-5-醇盐酸盐（ERA-923），可抑制他莫昔芬敏感和耐药肿瘤的生长，且在小鼠和大鼠中无促子宫生长作用。

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Importance of the alkylaminoethoxy side-chain for the estrogenic and antiestrogenic actions of tamoxifen and trioxifene in the immature rat uterus.

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Studies on the mechanism of action of the nonsteroidal antioestrogen tamoxifen (I.C.I. 46,474) in the rat.关于非甾体抗雌激素他莫昔芬（I.C.I. 46,474）在大鼠体内作用机制的研究。

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Activation of 4-hydroxytamoxifen and the tamoxifen derivative metabolite E by uterine peroxidase to form DNA adducts: comparison with DNA adducts formed in the uterus of Sprague-Dawley rats treated with tamoxifen.

Carcinogenesis. 1996 Sep;17(9):1785-90. doi: 10.1093/carcin/17.9.1785.

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