Wright J W, Harding J W
Science. 1982 Apr 16;216(4543):322-4. doi: 10.1126/science.7063891.
Mice were trained to discriminate between scented and unscented air. After olfactory bulbs were removed, discrimination was lost, but returned with the formation of synaptic connections between regenerated primary olfactory neurons and the cortex of the forebrain. The acquisition of a second olfactory-mediated task by long-term bulbectomized mice and controls was indistinguishable. The results emphasize the plasticity of the nervous system, correlate the presence of neural connections between olfactory mucosa and forebrain with the recovery of olfactory function, suggest that olfactory-mediated memory resides at least in part outside the olfactory bulbs, and demonstrate that the bulbs are not required for the acquisition of olfactory tasks.
小鼠被训练区分有气味和无气味的空气。切除嗅球后，这种辨别能力丧失，但随着再生的初级嗅觉神经元与前脑皮质之间形成突触连接，辨别能力又恢复了。长期切除嗅球的小鼠和对照组小鼠在获得第二项嗅觉介导任务方面没有区别。这些结果强调了神经系统的可塑性，将嗅觉黏膜与前脑之间神经连接的存在与嗅觉功能的恢复联系起来，表明嗅觉介导的记忆至少部分存在于嗅球之外，并证明获得嗅觉任务并不需要嗅球。
