新生期行嗅球切除且具有新的嗅觉-新皮质连接的大鼠没有嗅觉。

Neonatally bulbectomized rats with new olfactory-neocortical connections are anosmic.

作者信息

Butler A B, Graziadei P P, Monti Graziadei G A, Slotnick B M

出版信息

Neurosci Lett. 1984 Aug 10;48(3):247-54. doi: 10.1016/0304-3940(84)90046-6.

Abstract

Rats with one olfactory bulb removed when neonates and the second bulb removed when adults were tested on tone-light discrimination and odor detection tasks. On the neonatally operated side reconstituted olfactory receptor cell axons penetrated the frontal neocortex or portions of the anterior olfactory nucleus, and formed glomerular-like structures. On the adult operated side there was extensive scar formation which prevented in-growing sensory axons from contacting the brain. All experimental animals acquired the tone-light discrimination but failed to show any evidence of odor detection. These results indicate that reconstituted olfactory projections which terminate in the frontal neocortex or anterior olfactory nucleus do not support olfaction.

摘要

对新生时摘除一个嗅球、成年时摘除另一个嗅球的大鼠进行了音调-光辨别和气味检测任务测试。在新生时手术的一侧，重新构建的嗅觉受体细胞轴突穿透额叶新皮层或前嗅核的部分区域，并形成类似肾小球的结构。在成年时手术的一侧，有大量瘢痕形成，阻止了生长中的感觉轴突与大脑接触。所有实验动物都获得了音调-光辨别能力，但没有显示出任何气味检测的证据。这些结果表明，终止于额叶新皮层或前嗅核的重新构建的嗅觉投射不支持嗅觉。