Janik J S, Apkarian R, Nagaraj H S, Groff D B
Surg Gynecol Obstet. 1982 Apr;154(4):491-6.
The surface topography of rabbit enteric serosa was studied with a scanning electron microscope before and after surgical manipulation and after pretreatment with polyvinylpyrrolidone, an experimental antiadhesion agent. Results indicated that the serosal surface is characterized by an intertwined three-dimensional lattice of collagen like material which was remarkably altered by simple handling. Pretreatment with polyvinylpyrrolidone reduced this alteration, but polyvinylpyrrolidone itself has an adverse effect upon serosal topography. This study has provided novel insight into the fine structure of the intestinal serosa and has demonstrated alterations in this structure after simple operative handling. It has been shown that polyvinylpyrrolidone, although offering some protection, altered the fine latticework that covers the serosal surface. In addition, this study has demonstrated the usefulness of the scanning electron microscope in defining serosal damage and evaluating new therapeutic antiadhesion agents.
利用扫描电子显微镜研究了手术操作前后以及用实验性抗粘连剂聚乙烯吡咯烷酮预处理后兔肠浆膜的表面形貌。结果表明，浆膜表面的特征是由类似胶原的物质构成的三维交织晶格，简单的操作可使其发生显著改变。聚乙烯吡咯烷酮预处理可减少这种改变，但聚乙烯吡咯烷酮本身对浆膜形貌有不良影响。本研究为肠浆膜的精细结构提供了新的见解，并证明了简单手术操作后该结构的变化。研究表明，聚乙烯吡咯烷酮虽然提供了一定保护，但改变了覆盖浆膜表面的精细晶格结构。此外，本研究证明了扫描电子显微镜在确定浆膜损伤和评估新型治疗性抗粘连剂方面的实用性。
