Deen H G, Sundt T M
Stroke. 1982 Mar-Apr;13(2):179-84. doi: 10.1161/01.str.13.2.179.
We investigated the potential of aspirin and dipyridamole in combination to inhibit thrombus formation by comparing endarterectomized segments of 20 dog carotid arteries in animals treated with pre- and post-operative aspirin and dipyridamole to 20 arteries from untreated animals and 20 arteries from animals receiving intra-operative heparin. The temporal profile of thrombus formation was assessed by means of angiography, light microscopy, and scanning electron microscopy at time intervals ranging from 30 minutes to three months from the time of surgery. All of the aspirin-dipyridamole vessels remained patent and only one had significant gross thrombus formation. This contrasted to six occlusions and six significant gross thrombi in the control group and one occlusion and six significant gross thrombi in the heparin group. The combination of oral aspirin and dipyridamole minimizes thrombus formation in the highly thrombogenic lesion created by carotid endarterectomy in the dog.
我们通过比较20只狗颈动脉内膜切除术后节段在术前和术后使用阿司匹林和双嘧达莫治疗的动物与20只未治疗动物的动脉以及20只术中接受肝素治疗动物的动脉，研究了阿司匹林和双嘧达莫联合使用抑制血栓形成的潜力。通过血管造影、光学显微镜和扫描电子显微镜在术后30分钟至三个月的时间间隔内评估血栓形成的时间过程。所有使用阿司匹林 - 双嘧达莫的血管均保持通畅，只有1只出现明显的肉眼可见血栓形成。这与对照组的6只血管闭塞和6个明显的肉眼可见血栓以及肝素组的1只血管闭塞和6个明显的肉眼可见血栓形成形成对比。口服阿司匹林和双嘧达莫的联合使用可使犬颈动脉内膜切除术造成的高血栓形成病变中的血栓形成最小化。
