Malakhovskaia D B, Sviderskaia G E
Zh Vyssh Nerv Deiat Im I P Pavlova. 1982 Jan-Feb;32(1):115-21.
Effect of GABA on the motor activity of rats of the first month of life was studied in conditions of free behaviour in the maternal cage. It has been found that at the age of 1-10 days the injection of GABA increases, and at the age of 11-30 days decreases both the general motor activity and the grooming activity. It is suggested that a possible mechanism of the observed effect of GABA consists in the deepening of presynaptic inhibition, which results, during the earlier stages of postnatal ontogeny, in intensifying the autorhythmical activity of spinal motor centres, whereas during the later stages, when the autorhythmical activity of the spinal cord is replaced by reflex excitatory mechanisms, in depressing the latter.
在母鼠笼中自由行为的条件下，研究了γ-氨基丁酸（GABA）对出生后第一个月大鼠运动活动的影响。结果发现，在1-10日龄时，注射GABA会增加总体运动活动和梳理活动；而在11-30日龄时，注射GABA则会降低这两种活动。有人认为，GABA所观察到的效应的一种可能机制在于突触前抑制的加深，这在出生后个体发育的早期阶段会导致脊髓运动中枢的自律性活动增强，而在后期阶段，当脊髓的自律性活动被反射性兴奋机制取代时，则会抑制后者。
