Sviderskaia G E, Dmitrieva L E
Zh Evol Biokhim Fiziol. 1994 May-Jun;30(3):401-7.
During the first month of postnatal life, studies have been made of the effect of L-DOPA on grooming in rat puppies. It was found that within the first hour after injection of the drug, its inhibitory effect increases in the course of ontogenetic development. In some of the animals, the increase in grooming was observed, whereas in other ones the effect was absent. Inhibition concerns both the number of grooming outbursts and the duration of rhythmic phase. These changes are associated with the decrease of afferent input to the central nervous system and with inhibition of the activity of pacemakers of rhythmic motor excitation.
在出生后第一个月，研究了左旋多巴对新生大鼠梳理行为的影响。发现给药后第一小时内，其抑制作用在个体发育过程中增强。在一些动物中，观察到梳理行为增加，而在其他动物中则没有这种效果。抑制作用涉及梳理发作的次数和节律性阶段的持续时间。这些变化与中枢神经系统传入输入的减少以及节律性运动兴奋起搏器活动的抑制有关。
