Orsulakova A, Schacht J
Acta Otolaryngol. 1982 Jan-Feb;93(1-2):43-8. doi: 10.3109/00016488209130850.
The effects of neomycin on tissue levels of ethacrynic acid was studied in vivo and in vitro. In vitro, the addition of neomycin to incubations of synaptosomes and inner ear tissues of guinea pigs raised the concentration of bound ethacrynate approximately two-fold. In vivo, radioactive ethacrynate was determined in the inner ear of mice by radioautography after intravenous injection of the drug (50 mg/kg body weight). Treatment of animals with neomycin (100 mg/kg body weight, intramuscularly) 60 min prior to ethacrynate led to a three-to five-fold higher accumulation of ethacrynate in cochlear structures. It is suggested that neomycin breaks down hemolabyrinthine or tissue permeability barriers and allows increased penetration of the other drug into the inner ear.
研究了新霉素对依他尼酸组织水平的体内和体外效应。在体外，向豚鼠突触体和内耳组织培养物中添加新霉素可使结合型依他尼酸盐的浓度提高约两倍。在体内，静脉注射药物（50毫克/千克体重）后，通过放射自显影术测定小鼠内耳中的放射性依他尼酸。在注射依他尼酸前60分钟用新霉素（100毫克/千克体重，肌肉注射）处理动物，导致依他尼酸在耳蜗结构中的蓄积增加三至五倍。提示新霉素破坏血迷路或组织通透性屏障，使另一种药物向内耳的渗透增加。
