Morgenstern C, Miyamoto H, Arnold W, Vosteen K H
Acta Otolaryngol. 1982;93(1-6):187-94. doi: 10.3109/00016488209130870.
After obliteration of endolymphatic sac and duct, no significant alteration in d.c. potential, K+ activity or protein content during the development of endolymphatic hydrops could be observed. The K+ activity of endolymphatic sac was only one-ninth of that in the cochlear part of the endolymph. After injection of Thorotrast into the endolymphatic sac, aggregated particles were found in the cochlear endolymph 2 days later. Ethacrynic acid (60 mg/kg) caused a decrease in K+ activity in the cochlear endolymph, but an increase in the endolymphatic sac. Intercellular edema was observed both in stria vascularis and in endolymphatic sac by light and electronmicroscopy after ethacrynic acid administration. These results suggest the existence of an active transport mechanism in the endolymphatic sac epithelium.
在内淋巴囊和内淋巴管被闭塞后，在内淋巴积水形成过程中，未观察到直流电位、钾离子活性或蛋白质含量有明显变化。内淋巴囊的钾离子活性仅为内淋巴耳蜗部分的九分之一。将钍胶体注入内淋巴囊后，两天后在耳蜗内淋巴中发现聚集的颗粒。依他尼酸（60毫克/千克）导致耳蜗内淋巴中的钾离子活性降低，但内淋巴囊中的钾离子活性增加。给予依他尼酸后，通过光学显微镜和电子显微镜观察到血管纹和内淋巴囊中均出现细胞间水肿。这些结果表明内淋巴囊上皮中存在主动转运机制。
