Miller W H, Faust I M
Am J Physiol. 1982 Feb;242(2):E93-6. doi: 10.1152/ajpendo.1982.242.2.E93.
Rats raised in the cold showed an unusual pattern of adipose tissue morphology. Male Sprague-Dawley rats were maintained in a 5 degrees C environment for up to 24 wk and the cellularity of their major adipose depots was determined. Normal age-related increases in adipocyte number were absent in two major fat depots (retroperitoneal and inguinal), whereas there was a supranormal increase in a third (epididymal). This pattern of hyperplasia contrasts sharply with that seen in rats fed highly palatable high-fat or high-carbohydrate diets in which retroperitoneal depots show the most hyperplasia and epididymal pads the least. Such variations of response across depots suggest that the features of adipose tissue responsible for adipocyte proliferation in the various depots may not be homogeneous both in their nature and in their distribution.
在寒冷环境中饲养的大鼠呈现出一种不寻常的脂肪组织形态模式。将雄性斯普拉格-道利大鼠置于5摄氏度的环境中长达24周，并测定其主要脂肪储存部位的细胞构成。在两个主要脂肪储存部位（腹膜后和腹股沟），正常的与年龄相关的脂肪细胞数量增加并不存在，而在第三个部位（附睾周围）则出现了超常增加。这种增生模式与喂食高度可口的高脂肪或高碳水化合物饮食的大鼠形成鲜明对比，在后者中，腹膜后储存部位增生最为明显，而附睾周围脂肪垫增生最少。各储存部位反应的这种差异表明，负责不同储存部位脂肪细胞增殖的脂肪组织特征，在其性质和分布上可能并非均匀一致。
