Szczepańska-Sadowska E, Sobocińska J, Sadowski B
Am J Physiol. 1982 Mar;242(3):R372-9. doi: 10.1152/ajpregu.1982.242.3.R372.
The purpose of the present study was to investigate the possible role of vasopressin (ADH) in the control of thirst. With this aim spontaneous water intake (WI) was examined in conscious dogs after 1) electric stimulation in the basal forebrain causing release of ADH, 2) injection of 0.03, 0.05, 0.10, 0.15, 0.30, and 3.00 mU of ADH into the third cerebral ventricle (3rd V), 3) injection of 0.3, 3.0, and 30 mU of ADH into the lateral cerebral ventricle (LV) and injection of 5.0 and 10.0 mU of ADH into the carotid artery (CA). Stimulation through 10 of 16 electrodes located in various structures of the limbic system caused a significant increase in blood ADH, decrease of urine output, increase in renal free-water reabsorption, nonstimulus-bound drinking, positive water balance, and decrease in plasma osmolality (Posmol). Injection of ADH to the 3rd V caused a significant increase in WI. The maximum WI was observed after injection of 0.10-0.15 mU of ADH. Elevation of WI caused a significant decrease in Posmol 1 h after injection of ADH to the 3rd V. Insignificant increases or no changes in WI were observed when ADH was injected into the LV and CA, respectively. The results suggest that ADH may exert central dipsogenic effects.
本研究的目的是探讨血管加压素（抗利尿激素，ADH）在口渴控制中的可能作用。为此，对清醒犬的自发饮水量（WI）进行了检测，检测条件如下：1）电刺激基底前脑促使ADH释放；2）向第三脑室（3rd V）注射0.03、0.05、0.10、0.15、0.30和3.00 mU的ADH；3）向侧脑室（LV）注射0.3、3.0和30 mU的ADH，以及向颈动脉（CA）注射5.0和10.0 mU的ADH。对位于边缘系统不同结构的16个电极中的10个进行刺激，可导致血液中ADH显著增加、尿量减少、肾脏自由水重吸收增加、无刺激束缚的饮水增加、正水平衡以及血浆渗透压（Posmol）降低。向第三脑室注射ADH可使自发饮水量显著增加。注射0.10 - 0.15 mU的ADH后观察到最大自发饮水量。向第三脑室注射ADH 1小时后，自发饮水量的增加导致血浆渗透压显著降低。向侧脑室和颈动脉注射ADH时，分别观察到自发饮水量无显著增加或无变化。结果表明，ADH可能发挥中枢性致渴作用。
