Szczepańska-Sadowska E, Sadowski B, Sobocińska J
J Physiol (Paris). 1981 Sep;77(6-7):671-4.
Seven dogs were chronically implanted with 30 electrodes directed at various structures of the basal forebrain. Osmotic thirst threshold (expressed as an increase in plasma osmolality and a decrease in cellular water content caused by an intravenous infusion of 5% NaCl, necessary to induce drinking) was measured during electric stimulation of the basal forebrain and compared to that found under control conditions. Stimulation through 11 electrodes located in the lateral part of the septum (5 locations) and other parts of the limbic system markedly decreased the osmotic thirst threshold. The increment in plasma osmolality necessary to elicit drinking decreased from 9.7 +/- 1.3 to 4.8 +/- 1.2 mmol/kg (n = 11). The volume of water drunk at the thirst threshold did not differ significantly. A significant augmentation of the volume of water drunk during 1 h following infusion of hypertonic saline was observed when the infusion was combined with stimulation of the gyrus rectus, precommissural septum and nucleus accumbens. These and previous results (SZCZEPANSKA-SADOWSKA et al., 1979) suggest that the limbic system of the basal forebrain exerts both excitatory and inhibitory influences on the thirst system. The prolonged poststimulatory overdrinking indicates that enhancement of osmotic thirst cannot be entirely explained by an immediate action of the stimulating current on the neurons of the thirst system.
七只狗被长期植入30个电极，这些电极指向基底前脑的不同结构。在对基底前脑进行电刺激期间，测量了渗透渴阈值（通过静脉输注5%氯化钠诱导饮水时，以血浆渗透压升高和细胞内含水量降低来表示），并与对照条件下的结果进行比较。通过位于隔膜外侧部分（5个位置）和边缘系统其他部分的11个电极进行刺激，显著降低了渗透渴阈值。引发饮水所需的血浆渗透压升高从9.7±1.3降至4.8±1.2 mmol/kg（n = 11）。渴阈值时的饮水量没有显著差异。当输注高渗盐水与刺激直回、连合前隔膜和伏隔核相结合时，观察到输注后1小时内饮水量显著增加。这些结果以及之前的结果（SZCZEPANSKA - SADOWSKA等人，1979年）表明，基底前脑的边缘系统对渴觉系统既有兴奋性影响，也有抑制性影响。刺激后长时间的过量饮水表明，渗透渴觉的增强不能完全用刺激电流对渴觉系统神经元的即时作用来解释。
