Corbett S W, Keesey R E
Am J Physiol. 1982 Apr;242(4):E273-9. doi: 10.1152/ajpendo.1982.242.4.E273.
Rats with lateral hypothalamic (LH) lesions maintain body weight at a chronically reduced percentage of nonlesioned controls. An assessment of how they achieve energy balance at subnormal weight levels entailed a determination of both their energy intake and their energy expended or lost in processing ingested food, on basal heat production, on activity, and in feces or urine. It was found that the caloric intake and expenditure of LH-lesioned animals, though significantly lower than those of controls, were appropriate to the reduced metabolic body size (BW0.75) that they maintained. Likewise, energy expenditure in the LH-lesioned animals was normal in that the proportion of their ingested energy relegated to 1) basal metabolism, 2) the processing food, and 3) activity was the same as that of nonlesioned controls. Thus, unlike nonlesioned rats, which at lowered body weights both decrease their energy needs and reorder the pattern of energy expenditure, LH-lesioned animals display a normal pattern of energy utilization at reduced weight levels. These findings provide further evidence that lateral hypothalamic mechanisms play an important role in setting the level at which body weight is regulated.
患有下丘脑外侧（LH）损伤的大鼠，其体重维持在低于未损伤对照组的长期降低水平。评估它们在体重低于正常水平时如何实现能量平衡，需要确定它们的能量摄入以及在处理摄入食物、基础产热、活动以及粪便或尿液中所消耗或损失的能量。研究发现，LH损伤动物的热量摄入和消耗虽然显著低于对照组，但与它们维持的降低的代谢体重（体重的0.75次方）相适应。同样，LH损伤动物的能量消耗是正常的，因为它们摄入能量中分配到1）基础代谢、2）处理食物和3）活动的比例与未损伤对照组相同。因此，与体重降低时既降低能量需求又重新调整能量消耗模式的未损伤大鼠不同，LH损伤动物在体重降低水平时表现出正常的能量利用模式。这些发现进一步证明下丘脑外侧机制在设定体重调节水平方面发挥着重要作用。
