Corbett S W, Keesey R E
Physiol Behav. 1980 Jun;24(6):1165-8. doi: 10.1016/0031-9384(80)90065-7.
The body weight of male rats with lateral hypothalamic lesions remained approximately 20% below that maintained by nonlesioned controls. One month following surgery, both food intake and energy losses in feces and urine were measured in all animals for five days. The percentage of ingested food absorbed by the gut ("digestibility") was determined from calorimetric analysis of the feces to be slightly, though significantly, higher for the lesioned animals (79.7% vs 77.4%). Resorptive capacity, as indicated by the percentage of absorbed energy lost in the urine, was determined to be the same for the lesioned and control animals (4.8% vs 4.5%). These results indicate that the digestive, absorptive, and resorptive processes of LH-lesioned animals are at least as efficient as those of nonlesioned animals maintaining normal body weights. Thus, though LH-lesioned animals are reported to display various gastrointestinal dysfunctions, alterations in digestive or resorptive efficiency are apparently not responsible for their chronically-reduced body weights.
下丘脑外侧损伤的雄性大鼠体重比未损伤的对照组大鼠低约20%。手术后一个月，对所有动物进行为期五天的食物摄入量以及粪便和尿液中的能量损失测量。通过对粪便进行量热分析确定肠道吸收的摄入食物百分比（“消化率”），结果显示，损伤组动物的消化率略高，但具有显著差异（79.7%对77.4%）。以尿液中损失的吸收能量百分比表示的重吸收能力在损伤组和对照组动物中相同（4.8%对4.5%）。这些结果表明，下丘脑外侧损伤动物的消化、吸收和重吸收过程至少与维持正常体重的未损伤动物一样有效。因此，尽管据报道下丘脑外侧损伤的动物会出现各种胃肠功能障碍，但消化或重吸收效率的改变显然不是其体重长期减轻的原因。
