Malo J L, Zeiss C R
Am Rev Respir Dis. 1982 Jan;125(1):113-6. doi: 10.1164/arrd.1982.125.1.113.
A foundry worker developed dyspnea and a restrictive breathing defect after being exposed to diphenylmethane diisocyanate (MD) at work. His symptoms and lung function impairment subsided a few weeks after he left work. Specific inhalation challenges with the offending agent induced general malaise together with a significant increase in body temperature and leukocyte count as well as a significant decrease in forced vital capacity and transfer factor. Total antibody activity to a MDI human serum albumin (MDI-HSA) conjugate was detected by ammonium sulfate precipitation. Specific IgG antibodies were demonstrated by the enzyme-linked immunoabsorbent (ELISA) technique. Thus, it was found that MDI exposure can cause hypersensitivity pneumonitis and induce the production of specific antibodies.
一名铸造工人在工作中接触二苯基甲烷二异氰酸酯（MDI）后出现呼吸困难和限制性呼吸缺陷。他离职几周后，症状和肺功能损害有所缓解。用致病因子进行特异性吸入激发试验，引发了全身不适，同时体温和白细胞计数显著升高，用力肺活量和转移因子显著下降。通过硫酸铵沉淀法检测了针对MDI人血清白蛋白（MDI-HSA）偶联物的总抗体活性。用酶联免疫吸附（ELISA）技术证实了特异性IgG抗体的存在。因此，发现接触MDI可导致过敏性肺炎并诱导特异性抗体的产生。
