Cvitanović S, Zekan L, Marusić M
Department for Pulmonary Diseases, Firule Clinical Center, Split, Yugoslavia.
Int Arch Occup Environ Health. 1989;61(7):483-6. doi: 10.1007/BF00386483.
The levels of IgE antibodies specific for toluene-diisocyanate (TDI), diphenylmethane-diisocyanate (MDI) and hexamethylene-diisocyanate (HDI) were determined in eight workers with an unequivocal history of professional asthma, all having been exposed to isocyanates in the working atmosphere. Five workers were examined at the clinical onset of asthma. They had serum IgE antibodies specific for TDI, MDI and HDI, and depressed pulmonary ventilation parameters. In contrast, three workers, who had only a mild bronchial obstruction at the time of testing, had no anti-isocyanate IgE antibodies. The results indicated that asthma was induced by type I allergic reaction, but other pathogenetic mechanisms of bronchoobstruction could not be completely ruled out.
在八名有明确职业性哮喘病史的工人中测定了针对甲苯二异氰酸酯（TDI）、二苯基甲烷二异氰酸酯（MDI）和六亚甲基二异氰酸酯（HDI）的IgE抗体水平，所有这些工人在工作环境中均接触过异氰酸酯。五名工人在哮喘临床发作时接受了检查。他们具有针对TDI、MDI和HDI的血清IgE抗体，并且肺通气参数降低。相比之下，三名在测试时仅有轻度支气管阻塞的工人没有抗异氰酸酯IgE抗体。结果表明，哮喘是由I型过敏反应诱发的，但支气管阻塞的其他发病机制也不能完全排除。
