Feldman H, Guignard J P
Arch Dis Child. 1982 Feb;57(2):123-6. doi: 10.1136/adc.57.2.123.
The creatinine-kinetics method of analysis was used to study the changes, during the first month of life, in plasma creatinine levels in 34 newborn infants receiving no treatment with drugs. Plasma creatinine values during the first 5 days of life ranged from 188 to 17 mumol/l. After day 5 plasma levels were fairly stable throughout the first month, with a mean value of 35 +/- 2 (range 12-62) mumol/l. Twenty-two infants receiving treatment with gentamicin-ampicillin-cloxacillin were also studied. Seven of them had raised plasma creatinine concentrations after day 5, well beyond the range of concentrations found for infants receiving no drugs. Plasma creatinine, measured by the kinetic method, appears to provide a useful index of renal function in the neonatal period.
采用肌酐动力学分析方法，对34名未接受药物治疗的新生儿出生后第一个月内血浆肌酐水平的变化进行了研究。出生后前5天血浆肌酐值范围为188至17μmol/L。5天后，血浆水平在第一个月内相当稳定，平均值为35±2（范围12 - 62）μmol/L。还对22名接受庆大霉素 - 氨苄青霉素 - 氯唑西林治疗的婴儿进行了研究。其中7名婴儿在5天后血浆肌酐浓度升高，远超未接受药物治疗婴儿的浓度范围。通过动力学方法测量的血浆肌酐似乎为新生儿期肾功能提供了一个有用的指标。
