Sertel H, Scopes J
Arch Dis Child. 1973 Sep;48(9):717-20. doi: 10.1136/adc.48.9.717.
Rates of creatinine clearance were measured in normal newborn babies by collecting a timed specimen of voided urine and estimating plasma creatinine. Each of the 17 babies had the estimation on day 1 and on day 6 of life. The mean rate on day 1 was 17·8 ml/minute per 1·73 m, and there was a significant and systematic increase by day 6 when the mean rate was 36·4 ml/minute per 1·73 m. The findings are important when assessing fluid requirements and drug dosage in the newborn.
通过收集定时的晨尿样本并估算血浆肌酐,来测量正常新生儿的肌酐清除率。17名婴儿均在出生第1天和第6天进行了该项估算。出生第1天的平均清除率为每1.73平方米17.8毫升/分钟,到第6天有显著且系统性的增加,平均清除率为每1.73平方米36.4毫升/分钟。这些发现对于评估新生儿的液体需求量和药物剂量具有重要意义。