Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan.
Center for Integrated Science and Humanities, Fukushima Medical University, Fukushima, Japan.
PLoS One. 2018 May 24;13(5):e0196721. doi: 10.1371/journal.pone.0196721. eCollection 2018.
We investigated the relationship of neonatal and maternal serum creatinine (nSCr and mSCr, respectively) with various maternal/infant characteristics at different gestational ages (GA). We reviewed medical records of neonates admitted to NICU. We collected data on birth weight, GA, Apgar scores, medications, etc. Spearman's test was used to analyze the correlation between serum creatinine and continuous variables, and the Mann-Whitney U and Kruskal-Wallis tests for continuous variables between groups. The changes in nSCr, mSCr, and nSCr/mSCr ratio because of gestational age and the points in gestational changes in trends were estimated using joinpoint trend analysis. From 614 neonate and mother pairs, we found that nSCr was significantly correlated with GA. However, mSCr at >28 wks decreased with GA. The nSCr/mSCr ratio was correlated with GA. In infants born <29 weeks, pregnancy-induced hypertension (PIH) (p = 0.000, β = 0.20) and mSCr (p = 0.000, β = 0.73) were significantly associated with nSCr. In term infants, maternal magnesium administration (p = 0.000, β = 0.25), respiratory distress syndrome (p = 0.013, β = 0.16), PIH (p = 0.005, β = 0.19), and mSCr (p = 0.000, β = 0.33) were significantly associated with nSCr. nSCr reflected mSCr at all gestational ages. The correlation between nSCr and mSCr in preterm infants (p = 0.000, β = 0.74) was stronger than in term infants (p = 0.000, β = 0.34).
我们研究了新生儿和产妇血清肌酐（nSCr 和 mSCr）与不同孕龄（GA）下的各种产妇/新生儿特征之间的关系。我们回顾了新生儿重症监护病房（NICU）收治的新生儿的病历。我们收集了出生体重、GA、阿普加评分、用药等数据。使用 Spearman 检验分析血清肌酐与连续变量之间的相关性，组间连续变量采用 Mann-Whitney U 和 Kruskal-Wallis 检验。使用 Joinpoint 趋势分析估计血清肌酐、mSCr 以及 nSCr/mSCr 比值因 GA 而发生的变化以及 GA 变化趋势中的拐点。从 614 对新生儿和母亲中，我们发现 nSCr 与 GA 显著相关。然而，>28 周的 mSCr 随 GA 降低。nSCr/mSCr 比值与 GA 相关。在<29 周出生的婴儿中，妊娠高血压（PIH）（p = 0.000，β = 0.20）和 mSCr（p = 0.000，β = 0.73）与 nSCr 显著相关。在足月婴儿中，母亲镁剂的应用（p = 0.000，β = 0.25）、呼吸窘迫综合征（p = 0.013，β = 0.16）、PIH（p = 0.005，β = 0.19）和 mSCr（p = 0.000，β = 0.33）与 nSCr 显著相关。nSCr 反映了所有 GA 下的 mSCr。早产儿中 nSCr 与 mSCr 的相关性（p = 0.000，β = 0.74）强于足月儿（p = 0.000，β = 0.34）。
